Raws li tus neeg nqa khoom tseem ceeb hauv cov tshuaj niaj hnub no,enteric-coatedtshuaj ntsiavyog dav siv nyob rau hauv kev lag luam kws tshuaj vim lawv qhov zoo, xws li qhov chaw meej- tso tawm tshwj xeeb, tiv thaiv cov tshuaj los ntawm kev puas tsuaj los ntawm gastric acid, thiab tiv thaiv cov tshuaj los ntawm kev ua rau lub plab mucosa. Txawm li cas los xij, thaum lub sijhawm tsim khoom thiab khaws cia, lub sijhawm tawg ntawm enteric capsules feem ntau yog qhov qhia tau zoo uas nyuaj rau tswj. Kev ncua qeeb lossis kev tso tawm ntxov ntxov cuam tshuam ncaj qha rau bioavailability thiab kho cov txiaj ntsig ntawm cov tshuaj. Yog li, dab tsi yog yam tseem ceeb uas cuam tshuam rau kev puas tsuaj ntawm enteric-coated capsules?
Ua ntej thiab qhov tseem ceeb, qhov muaj pes tsawg leeg thiab cov khoom ntawm cov khoom siv plhaub yog qhov tseem ceeb hauv kev txiav txim siab kev ua haujlwm tsis zoo.Enteric capsulesfeem ntau sivgelatinRaws li cov khoom siv hauv paus, ntxiv nrog cov khoom siv polymers xws li acrylic resins, cellulose acetate phthalate (CAP), lossis shellac. Kev tawg ntawm cov khoom siv enteric no nyob ntawm tus nqi pH ntawm txoj hnyuv ib puag ncig. Yog tias qhov sib piv ntawm cov khoom siv txheej txheej enteric tsis tsim nyog-piv txwv li, yog tias qhov sib piv ntawm cov yeeb yaj kiab- ua cov neeg ua haujlwm siab dhau - nws tuaj yeem ua rau lub plhaub tsis tuaj yeem yaj lossis tawg sai hauv cov kua hauv cov hnyuv, yog li ua rau kev tawg mus dhau lub sijhawm txwv. Tsis tas li ntawd, gelatin nws tus kheej tawg lub zog, viscosity, thiab qib ntawm tus ntoo khaub lig- txuas cov kev cuam tshuam kuj cuam tshuam ncaj qha rau cov dej nqus thiab dispersibility ntawm lub plhaub capsule.
Thib ob,cov txheej txheem ntau lawmthiab kev cia khoom ua lub luag haujlwm tseem ceeb. Hauv cov txheej txheem tshuaj ntsiav molding, tswj qhov ziab kom qhuav thiab lub sijhawm yog qhov tseem ceeb tshwj xeeb. Kev ziab ntau dhau tuaj yeem ua rau cov dej noo ntau dhau hauv lub plhaub, ua rau nws nkig thiab tawv heev, uas cuam tshuam rau nws cov ntub dej thiab nkag mus los ntawm cov kua hauv lub cev; conversely, cov dej noo ntau dhau tuaj yeem ua rau lub plhaub muag muag lossis deform. Qhov tseem ceeb tshaj plaws yog tias cov av noo, qhov kub thiab txias hauv lub teebchaw cia khoomtuaj yeem ua rau "cross-linking" cov tshuaj tiv thaiv hauv gelatin. Tus ntoo khaub lig- txuas cov nyhuv no tsim cov dej- cov qauv tsis sib xws ntawm lub plhaub ntawm lub plhaub, ua rau cov tshuaj ntsiav tsis nqus dej thiab tawg ib txwm tom qab nkag mus rau tib neeg lub cev, ib qho tshwm sim uas feem ntau hu ua "insolubility".
Thaum kawg, cov khoom ntawm cov khoom ntim tsis tuaj yeem tsis quav ntsej. Txawm hais tias disintegration feem ntau tsom rau lub plhaub, qhov cuam tshuam ntawm cov ntsiab lus yog lub hom phiaj tseeb. Yog hais tias cov tshuaj muaj zog acidity los yog alkalinity, los yog muaj siab concentrations ntawm aldehydes, nws yuav ua rau kom cov tshuaj tiv thaiv kab mob nrog lub plhaub cov khoom, compromising lub stability ntawm lub enteric txheej. Qhov no tuaj yeem ua rau ntxov ntxov rupture nyob rau hauv lub plab los yog cuam tshuam ib txwm tso tawm nyob rau hauv cov hnyuv.
Hauv cov ntsiab lus, cov yam tseem ceeb cuam tshuam rau kev tawg ntawm enteric khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob. Cov tuam txhab lag luam yuav tsum nruj me ntsis tswj cov khoom siv raw zoo, ua kom cov txheej txheem ziab kom zoo, thiab ua kom qhov chaw txias thiab qhuav. Tsuas yog los ntawm kev tswj hwm cov yam tseem ceeb no tuaj yeem ua kom ntseeg tau tias enteric -cov tshuaj ntsiav uas muaj cov coated disintegrate thiab tso tawm kom meej thiab ua tau zoo hauv lub cev, yog li lav qhov kev ua tau zoo ntawm cov tshuaj.
